Article
The S. cerevisiae SAGA complex functions in vivo as a coactivator for transcriptional activation by Gal4.
Genes & development - 1 Aug 2001
Larschan E, Winston F
Abstract excerpt
Previous studies demonstrated that the SAGA (Spt-Ada-Gcn5-Acetyltransferase) complex facilitates the binding of TATA-binding protein (TBP) during transcriptional activation of the GAL1 gene of Saccharomyces cerevisiae. TBP binding was shown to require the SAGA components Spt3 and Spt20/Ada5, but not the SAGA component Gcn5. We have now examined whether SAGA is directly required as a coactivator in vivo by using...
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