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Article

p21 Disrupts the interaction between cdk2 and the E2F-p130 complex.

Molecular and cellular biology - 1 Mar 1996

Shiyanov P, Bagchi S, Adami G, Kokontis J, Hay N, Arroyo M, Morozov A, Raychaudhuri P

Abstract excerpt

In nonproliferating or growth-arrested cells, the transcription factor E2F remains bound to the retinoblastoma-related protein p130. Accumulation of this E2F-p130 complex correlates with an arrest of the cell cycle progression. Progression through G1 phase is associated with a cyclin-dependent binding of the cyclin-dependent kinase cdk2 to the E2F-p130 complex. By fractionating mouse L-cell extracts, we have...

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Identifiers

PMID: 8622674
DOI: 10.1128/MCB.16.3.737
PMCID: PMC231053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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p21 Disrupts the interaction between cdk2 and the E2F-p130 complex.PMID 8622674Read ↗

Inhibition of E2F activity by the cyclin-dependent protein kinase inhibitor p21 in cells expressing or lacking a functional retinoblastoma protein.Semantic proximity Read ↗

E2f1, E2f2, and E2f3 control E2F target expression and cellular proliferation via a p53-dependent negative feedback loop.Semantic proximity Read ↗

Cell cycle expression and p53 regulation of the cyclin-dependent kinase inhibitor p21.Semantic proximity Read ↗

p21 contains independent binding sites for cyclin and cdk2: both sites are required to inhibit cdk2 kinase activity.Semantic proximity Read ↗

Mitotic p21Cip1/CDKN1A is regulated by cyclin-dependent kinase 1 phosphorylation.Semantic proximity Read ↗

Phosphorylation of p21 in G2/M promotes cyclin B-Cdc2 kinase activity.Semantic proximity Read ↗

p21 is a critical CDK2 regulator essential for proliferation control in Rb-deficient cells.Semantic proximity Read ↗

The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway.Semantic proximity Read ↗

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In vitro transcriptional activation of p21 promoter by p53.Semantic proximity Read ↗

Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2Semantic proximity Read ↗

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