Article
The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway.
Genes & development - 1 Dec 1996
Hofmann F, Martelli F, Livingston D M, Wang Z
Abstract excerpt
E2F-1 plays a crucial role in the regulation of cell-cycle progression at the G1-S transition. In keeping with the fact that, when overproduced, it is both an oncoprotein and a potent inducer of apoptosis, its transcriptional activity is subject to multiple controls. Among them are binding by the retinoblastoma gene product (pRb), activation by cdk3, and S-phase-dependent down-regulation of DNA-binding capacity...
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