Chromosome 17 allelic loss and NF1-GRD mutations do not play a significant role as molecular mechanisms leading to melanoma tumorigenesis.

doi:10.1111/1523-1747.ep12343578

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Article

Chromosome 17 allelic loss and NF1-GRD mutations do not play a significant role as molecular mechanisms leading to melanoma tumorigenesis.

The Journal of investigative dermatology - 1 Mar 1996

Gómez L, Rubio M P, Martin M T, Vázquez J J, Idoate M, Pastorfide G, Pestaña A, Seizinger B R, Barnhill R L, Castresana J S

Abstract excerpt

Allelic loss in human cutaneous melanoma has been detected on chromosomes 1p, 6q, 9p, 10q, and 11q. Chromosome 17 contains important tumor suppressor genes such as p53, NM23, and neurofibromatosis type 1 (NF1), which have been implicated in melanoma tumorigenesis. The role of p53 has already been...

Topics

Alleles
Chromosomes, Human, Pair 17
DNA, Neoplasm
GTPase-Activating Proteins
Genes, Neurofibromatosis 1
Heterozygote
Humans
Melanoma
Mutation
Point Mutation
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
Proteins

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Open in PubMed

Identifiers

PMID: 8648172
DOI: 10.1111/1523-1747.ep12343578

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8648172-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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