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Article

A novel family of TRF (DNA topoisomerase I-related function) genes required for proper nuclear segregation.

Nucleic acids research - 15 Jun 1996

Castaño I B, Heath-Pagliuso S, Sadoff B U, Fitzhugh D J, Christman M F

Abstract excerpt

We recently reported the identification of a gene, TRF4 (for DNA topoisomerase related function), in a screen for mutations that are synthetically lethal with mutations in DNA topoisomerase I (top1). Here we describe the isolation of a second member of the TRF4 gene family, TRF5. Overexpression of TRF5 complements the inviability of top1 trf4 double mutants. The predicted Trf5 protein is 55% identical and 72%...

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Identifiers

PMID: 8710513
DOI: 10.1093/nar/24.12.2404
PMCID: PMC145947

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