Article
A novel family of TRF (DNA topoisomerase I-related function) genes required for proper nuclear segregation.
Nucleic acids research - 15 Jun 1996
Castaño I B, Heath-Pagliuso S, Sadoff B U, Fitzhugh D J, Christman M F
Abstract excerpt
We recently reported the identification of a gene, TRF4 (for DNA topoisomerase related function), in a screen for mutations that are synthetically lethal with mutations in DNA topoisomerase I (top1). Here we describe the isolation of a second member of the TRF4 gene family, TRF5. Overexpression o...
Topics
- Amino Acid Sequence
- Cell Nucleus
- DNA Topoisomerases, Type I
- Gene Expression
- Genetic Complementation Test
- Genome, Fungal
- Humans
- Mitosis
- Molecular Sequence Data
- Multigene Family
- Mutation
- Saccharomyces cerevisiae
- Sequence Homology, Amino Acid