Genotype relative risks: methods for design and analysis of candidate-gene association studies.

Abstract excerpt

Design and analysis methods are presented for studying the association of a candidate gene with a disease by using parental data in place of nonrelated controls. This alternative design eliminates spurious differences in allele frequencies between cases and nonrelated controls resulting from different ethnic origins and population stratification for these two groups. We present analysis methods which are based on...

Topics

• Genetic Diseases, Inborn
• Genotype
• Heterozygote
• Homozygote
• Humans
• Risk