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Article

Intergenic splicing of MDS1 and EVI1 occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family.

20 Feb 1996

Abstract excerpt

The EVI1 gene, located at chromosome band 3q26, is overexpressed in some myeloid leukemia patients with breakpoints either 5' of the gene in the t(3;3)(q21;q26) or 3' of the gene in the inv(3)(q21q26). EVI1 is also expressed as part of a fusion transcript with the transcription factor AML1 in the t(3;21)(q26;q22), associated with myeloid leukemia. In cells with t(3;21), additional fusion transcripts are AML1-MDS1...

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Identifiers

PMID: 8643684
DOI: 10.1073/pnas.93.4.1642

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Related research

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Intergenic splicing of MDS1 and EVI1 occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family.PMID 8643684Read ↗

High EVI1 expression predicts poor survival in acute myeloid leukemia: a study of 319 de novo AML patientsSemantic proximity Read ↗

Repression of RUNX1 Activity by EVI1: A New Role of EVI1 in LeukemogenesisSemantic proximity Read ↗

Expression and prognostic significance of different mRNA 5′‐end variants of the oncogene <i>EVI1</i> in 266 patients with de novo AML: <i>EVI1</i> and <i>MDS1/EVI1</i> overexpression both predict short remission durationSemantic proximity Read ↗

The leukaemia‐associated transcription factors EVI‐1 and MDS1/EVI1 repress transcription and interact with histone deacetylaseSemantic proximity Read ↗

A novel gene, MEL1, mapped to 1p36.3 is highly homologous to the MDS1/EVI1 gene and is transcriptionally activated in t(1;3)(p36;q21)-positive leukemia cellsSemantic proximity Read ↗

Aberrant EVI1 splicing contributes to EVI1-rearranged leukemiaSemantic proximity Read ↗

High EVI1 expression predicts outcome in younger adult patients with acute myeloid leukemia and is associated with distinct cytogenetic abnormalities.Semantic proximity Read ↗

Global Identification of EVI1 Target Genes in Acute Myeloid LeukemiaSemantic proximity Read ↗

A novel EVI1 gene family, MEL1, lacking a PR domain (MEL1S) is expressed mainly in t(1;3)(p36;q21)-positive AML and blocks G-CSF–induced myeloid differentiationSemantic proximity Read ↗

Expression of EVI1 in myelodysplastic syndromes and other hematologic malignancies without 3q26 translocationsSemantic proximity Read ↗

Novel <i>RUNX1‐PRDM16</i> fusion transcripts in a patient with acute myeloid leukemia showing t(1;21)(p36;q22)Semantic proximity Read ↗

EVI1-rearranged acute myeloid leukemias are characterized by distinct molecular alterations.Semantic proximity Read ↗

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