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Article

Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia

16 Jun 2022

Abstract excerpt

Detailed genomic and epigenomic analyses of MECOM (the MDS1 and EVI1 complex locus) have revealed that inversion or translocation of chromosome 3 drives inv(3)/t(3;3) myeloid leukemias via structural rearrangement of an enhancer that upregulates transcription of EVI1. Here, we identify a novel, previously unannotated oncogenic RNA-splicing derived isoform of EVI1 that is frequently present in inv(3)/t(3;3) acute...

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PMID: 35709354
DOI: 10.1182/blood.2021015325

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Aberrant EVI1 splicing contributes to EVI1-rearranged leukemiaPMID 35709354Read ↗

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