Expression and prognostic significance of different mRNA 5′‐end variants of the oncogene <i>EVI1</i> in 266 patients with de novo AML: <i>EVI1</i> and <i>MDS1/EVI1</i> overexpression both predict short remission duration

Abstract excerpt

Rearrangements of chromosome band 3q26.2 lead to overexpression of the EVI1 gene and are associated with a poor prognosis in myeloid malignancies. EVI1 is also overexpressed in some cases without 3q26 rearrangements. To uncover its prognostic significance in this patient group, however, it may be necessary to distinguish among several known 5'-end variants of its mRNA. According to a recent report, overexpression...

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