Article
High EVI1 expression predicts outcome in younger adult patients with acute myeloid leukemia and is associated with distinct cytogenetic abnormalities.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Apr 2010
Gröschel Stefan, Lugthart Sanne, Schlenk Richard F, Valk Peter J M, Eiwen Karina, Goudswaard Chantal, van Putten Wim J L, Kayser Sabine, Verdonck Leo F, Lübbert Michael, Ossenkoppele Gert-Jan, Germing Ulrich, Schmidt-Wolf Ingo, Schlegelberger Brigitte, Krauter Jürgen, Ganser Arnold, Döhner Hartmut, Löwenberg Bob, Döhner Konstanze, Delwel Ruud
Abstract excerpt
PURPOSE The purpose of this study was to investigate frequency and prognostic significance of high EVI1 expression in acute myeloid leukemia (AML). PATIENTS AND METHODS A diagnostic assay detecting multiple EVI1 splice variants was developed to determine the relative EVI1 expression by single rea...
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