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Article

MHC-DRB allelic sequences incorporate distinct intragenic trans-specific segments.

Tissue antigens - 1 Apr 1997

Gaur L K, Nepom G T, Snyder K E, Anderson J, Pandarpurkar M, Yadock W, Heise E R

Abstract excerpt

The second exon of primate MHC-DRB genes encodes discrete areas of allelic hypervariability (HVR), which are used as the basis for lineage assignments to determine genetic and evolutionary relationships. Comparisons of these regions have led to the "trans-species hypothesis", which proposes that certain MHC alleles from one species are more closely related to those from other species than they are to each other;...

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Identifiers

PMID: 9151386
DOI: 10.1111/j.1399-0039.1997.tb02762.x

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