Kinds of mutations induced by 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in the hprt gene of Chinese hamster ovary cells.

doi:10.1093/carcin/17.5.1179

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Article

Kinds of mutations induced by 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in the hprt gene of Chinese hamster ovary cells.

Carcinogenesis - 1 May 1996

Hyttinen J M, Myöhänen S, Jansson K

Abstract excerpt

The kinds of mutations induced by 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in the protein coding region of the hprt gene of Chinese hamster ovary (CHO) cells were determined by direct sequencing of polymerase chain reaction (PCR)-amplified cDNA. Primary mutations were found in 15...

Topics

Animals
Base Sequence
CHO Cells
Cricetinae
Furans
Hypoxanthine Phosphoribosyltransferase
Molecular Sequence Data
Mutagens
Mutation

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