Article
Splicing mutations in the CHO DHFR gene preferentially induced by (+/-)-3 alpha,4 beta-dihydroxy-1 alpha,2 alpha-epoxy-1,2,3,4- tetrahydrobenzo[c]phenanthrene.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1990
Carothers A M, Urlaub G, Mucha J, Harvey R G, Chasin L A, Grunberger D
Abstract excerpt
Cultured Chinese hamster ovary (CHO) cells were treated with the polycyclic aromatic hydrocarbon racemic 3 alpha,4 beta-dihydroxy-1 alpha,2 alpha-epoxy-1,2,3,4- tetrahydrobenzo[c]phenanthrene. Mutants deficient in dihydrofolate reductase activity were isolated. A carcinogen treatment at 0.1 micro...
Topics
- Animals
- Base Sequence
- Cell Line
- Cricetinae
- Cricetulus
- Enzyme Induction
- Female
- Gene Expression Regulation
- Genes
- Molecular Sequence Data
- Mutagens
- Mutation
- Oligonucleotide Probes
- Ovary
- Phenanthrenes