[Genetic polymorphisms in xenobiotic metabolizing enzymes as a determinant of susceptibility to environmental mutagens and carcinogens in humans].

doi:10.1248/yakushi1947.117.10-11_895

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Article

[Genetic polymorphisms in xenobiotic metabolizing enzymes as a determinant of susceptibility to environmental mutagens and carcinogens in humans].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan - 1 Nov 1997

Ozawa S

Abstract excerpt

Xenobiotic metabolizing enzymes are known to play a role in the metabolic activation of environmental mutagens and carcinogens to exert their carcinogenic effects as well as detoxification by increasing their hydrophilicity. These enzymes include cytochrome P450s, glutathione S-transferases (GSTs...

Topics

Acetyltransferases
Cytochrome P-450 Enzyme System
Disease Susceptibility
Glutathione Transferase
Humans
Mutagens
Mutation
Neoplasms
Polymorphism, Genetic
Sulfotransferases
Xenobiotics

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