Article
[Genetic and phenotypic polymorphisms in carcinogen-metabolizing enzymes and cancer susceptibility].
Nihon rinsho. Japanese journal of clinical medicine - 1 Aug 1996
Watanabe M
Abstract excerpt
Most of chemical carcinogens require metabolic activation before they interact with cellular macromolecules and can cause cancer initiation. Many of cytochrome P-450 (CYP) mediating oxidative enzymes and conjugation enzymes, cloned and characterized in humans, show genetic and phenotypic polymorp...
Topics
- Animals
- Arylamine N-Acetyltransferase
- Cytochrome P-450 CYP1A1
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 CYP2E1
- Disease Susceptibility
- Genotype
- Glutathione Transferase
- Humans
- Neoplasms
- Phenotype
- Polymorphism, Genetic
- Risk