Article
Downregulation of inhibitory SRC homology 2 domain-containing phosphatase-1 (SHP-1) leads to recovery of T cell responses in elderly.
Cell communication and signaling : CCS - 9 Jan 2014
Le Page Aurélie, Fortin Carl, Garneau Hugo, Allard Nancy, Tsvetkova Krassimira, Tan Crystal Tze Ying, Larbi Anis, Dupuis Gilles, Fülöp Tamas
Abstract excerpt
BACKGROUND: Immune responses are generally impaired in aged mammals. T cells have been extensively studied in this context due to the initial discovery of their reduced proliferative capacity with aging. The decreased responses involve altered signaling events associated with the early steps of T cell activation. The underlying causes of these changes are not fully understood but point to alterations in assembly...
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