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Article

Syk is a dual-specificity kinase that self-regulates the signal output from the B-cell antigen receptor.

Proceedings of the National Academy of Sciences of the United States of America - 26 Oct 2010

Heizmann Beate, Reth Michael, Infantino Simona

Abstract excerpt

Upon B-cell activation, the signaling subunits Ig-α and Ig-β of the B-cell antigen receptor become phosphorylated not only on tyrosines but also on serine residues. Using a specific antibody, we show that serine 197 (S197) in the cytoplasmic tail of Ig-α is phosphorylated upon B-cell antigen receptor activation, and that this modification inhibits the signal output of the B-cell antigen receptor. Surprisingly, we...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Intracellular Signaling Peptides and Proteins

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Share to Receptors, Antigen, B-Cell

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Source

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Identifiers

PMID: 20940318
DOI: 10.1073/pnas.1009048107
PMCID: PMC2972992

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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