Syk is a dual-specificity kinase that self-regulates the signal output from the B-cell antigen receptor.

doi:10.1073/pnas.1009048107

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Syk is a dual-specificity kinase that self-regulates the signal output from the B-cell antigen receptor.

Proceedings of the National Academy of Sciences of the United States of America - 26 Oct 2010

Heizmann Beate, Reth Michael, Infantino Simona

Abstract excerpt

Upon B-cell activation, the signaling subunits Ig-α and Ig-β of the B-cell antigen receptor become phosphorylated not only on tyrosines but also on serine residues. Using a specific antibody, we show that serine 197 (S197) in the cytoplasmic tail of Ig-α is phosphorylated upon B-cell antigen receptor activation, and that this modification inhibits the signal output of the B-cell antigen receptor. Surprisingly, we...

Topics

Amino Acid Sequence
Animals
B-Lymphocytes
CD79 Antigens
Cell Line
Drosophila
Intracellular Signaling Peptides and Proteins
Mice
Mice, Inbred BALB C
Mice, Knockout
Mice, Transgenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Molecular

Molecular Sequence Data

Mutation

Phosphorylation

Protein-Tyrosine Kinases

Receptors, Antigen, B-Cell

Recombinant Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 20940318
DOI: 10.1073/pnas.1009048107
PMCID: PMC2972992

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Syk is a dual-specificity kinase that self-regulates the signal output from the B-cell antigen receptor.PMID 20940318Read ↗

Spleen tyrosine kinase as a molecular target for treatment of leukemias and lymphomasSemantic proximity Read ↗

The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways.Semantic proximity Read ↗

The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development.Semantic proximity Read ↗

Generation of an analog-sensitive Syk tyrosine kinase for the study of signaling dynamics from the B cell antigen receptor.Semantic proximity Read ↗

The B cell receptor promotes B cell activation and proliferation through a non-ITAM tyrosine in the Igalpha cytoplasmic domain.Semantic proximity Read ↗

Novel<i>SYK</i>variant causes enhanced SYK autophosphorylation and PI3K activation in an antibody-deficient patientSemantic proximity Read ↗

TEC family kinases in health and disease--loss-of-function of BTK and ITK and the gain-of-function fusions ITK-SYK and BTK-SYK.Semantic proximity Read ↗

Signaling of the ITK (interleukin 2-inducible T cell kinase)-SYK (spleen tyrosine kinase) fusion kinase is dependent on adapter SLP-76 and on the adapter function of the kinases SYK and ZAP70.Semantic proximity Read ↗

Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice.Semantic proximity Read ↗

Altered BCR signalling quality predisposes to autoimmune disease and a pre-diabetic state.Semantic proximity Read ↗

Role of Syk in B-cell development and antigen-receptor signaling.Semantic proximity Read ↗

The role of Bruton’s tyrosine kinase in autoimmunity and implications for therapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.