Article
Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn).
Cell - 19 Apr 1991
Cooke M P, Abraham K M, Forbush K A, Perlmutter R M
Abstract excerpt
Engagement of the clonotypic antigen receptor (TCR) on T lymphocytes provokes an activation response leading to cell proliferation and lymphokine secretion. To examine the molecular basis of T cell signaling, we generated transgenic animals in which a lymphocyte-specific nonreceptor protein-tyrosine kinase p59fyn(T) is 20-fold overexpressed in developing T lineage cells. Thymocytes from these mice, analyzed using...
Topics
- Animals
- Antigens, Differentiation, T-Lymphocyte
- Calcium
- Cells, Cultured
- Genetic Vectors
- Humans
- Lymphocyte Activation
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Mice, Transgenic