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Article

Determination of life-span in Caenorhabditis elegans by four clock genes.

Science (New York, N.Y.) - 17 May 1996

Lakowski B, Hekimi S

Abstract excerpt

The nematode worm Caenorhabditis elegans is a model system for the study of the genetic basis of aging. Maternal-effect mutations in four genes--clk-1, clk-2, clk-3, and gro-1--interact genetically to determine both the duration of development and life-span. Analysis of the phenotypes of these mutants suggests the existence of a general physiological clock in the worm. Mutations in certain genes involved in dauer...

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Identifiers

PMID: 8638122
DOI: 10.1126/science.272.5264.1010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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