Article
Determination of life-span in Caenorhabditis elegans by four clock genes.
Science (New York, N.Y.) - 17 May 1996
Lakowski B, Hekimi S
Abstract excerpt
The nematode worm Caenorhabditis elegans is a model system for the study of the genetic basis of aging. Maternal-effect mutations in four genes--clk-1, clk-2, clk-3, and gro-1--interact genetically to determine both the duration of development and life-span. Analysis of the phenotypes of these mu...
Topics
- Aging
- Animals
- Biological Clocks
- Caenorhabditis elegans
- Genes, Helminth
- Genotype
- Longevity
- Mutation
- Phenotype
- Temperature