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Article

Characterization of a life-extending mutation in age-2, a new aging gene in Caenorhabditis elegans.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Apr 1999

Yang Y, Wilson D L

Abstract excerpt

We have generated a life-extending mutation, yw23, in Caenorhabditis elegans. The mutation is in what appears to be a new aging gene, which we have designated age-2. When homozygous, yw23 produces an increase of mean and maximum life span of about 20% over that of the wild-type strain, N2. Strain HG23 [age-2(yw23)] was obtained by screening for longer life spans among 430 lines of nematodes two generations after...

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PMID: 10219000
DOI: 10.1093/gerona/54.4.b137

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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