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Article

Molecular genetics of life span in C. elegans: how much does it teach us?

Trends in genetics : TIG - 1 Jan 1998

Hekimi S, Lakowski B, Barnes T M, Ewbank J J

Abstract excerpt

Several loci have been identified in the nematode worm Caenorhabditis elegans that, when mutated, can increase life span. Three of these genes, age-1, daf-2 and clk-1, have now been cloned. Mutations in these three genes are highly pleiotropic and affect many aspects of worm development and behav...

Topics

Amino Acid Sequence
Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Helminth Proteins
Life Expectancy
Longevity
Models, Genetic
Molecular Biology
Molecular Sequence Data
Mutation
Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats

Receptor, Insulin

Sequence Alignment

Sequence Homology, Nucleic Acid

Source

Identifiers

PMID: 9448461
DOI: 10.1016/S0168-9525(97)01299-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9448461-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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