Article
SOX3 is required during the formation of the hypothalamo-pituitary axis.
Nature genetics - 1 Mar 2004
Rizzoti Karine, Brunelli Silvia, Carmignac Danielle, Thomas Paul Q, Robinson Iain C, Lovell-Badge Robin
Abstract excerpt
The pituitary develops from the interaction of the infundibulum, a region of the ventral diencephalon, and Rathke's pouch, a derivative of oral ectoderm. Postnatally, its secretory functions are controlled by hypothalamic neurons, which also derive from the ventral diencephalon. In humans, mutations affecting the X-linked transcription factor SOX3 are associated with hypopituitarism and mental retardation, but...
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