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Article

Altered major histocompatibility complex class II peptide loading in H2-O-deficient mice.

European journal of immunology - 1 Oct 2000

Perraudeau M, Taylor P R, Stauss H J, Lindstedt R, Bygrave A E, Pappin D J, Ellmerich S, Whitten A, Rahman D, Canas B, Walport M J, Botto M, Altmann D M

Abstract excerpt

The biosynthesis of MHC class II/peptide complexes involves classical, cell surface MHC products as well as the intracellular component H2-M, required for the removal of invariant chain-derived CLIP and for peptide loading. The function of another intracellular class II heterodimer, H2-O, is the matter of some controversy. The physical association of H2-O with H2-M and co-localization in class II+ vesicles...

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Identifiers

PMID: 11069069
DOI: 10.1002/1521-4141(200010)30:10<2871::AID-IMMU2871>3.0.CO;2-B

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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