Article
A defect in glycosylphosphatidylinositol (GPI) transamidase activity in mutant K cells is responsible for their inability to display GPI surface proteins.
Proceedings of the National Academy of Sciences of the United States of America - 19 Mar 1996
Chen R, Udenfriend S, Prince G M, Maxwell S E, Ramalingam S, Gerber L D, Knez J, Medof M E
Abstract excerpt
The final step in the pathway that provides for glycosylphosphatidylinositol (GPI) anchoring of cell-surface proteins occurs in the lumen of the endoplasmic reticulum and consists of a transamidation reaction in which fully assembled GPI anchor donors are substituted for specific COOH-terminal signal peptide sequences contained in nascent polypeptides. In previous studies we described a human K562 cell mutant...
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