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Article

Defective galactofuranose addition in lipophosphoglycan biosynthesis in a mutant of Leishmania donovani.

The Journal of biological chemistry - 15 Nov 1993

Huang C, Turco S J

Abstract excerpt

A mutant cell line of Leishmania donovani (R2D2), previously selected for resistance to the cytotoxic lectin ricin agglutinin, was found to be totally deficient in the synthesis and expression of lipophosphoglycan, a dominant surface virulence factor. The metabolic defect in R2D2 parasites responsible for its lipophosphoglycan (LPG-) phenotype was investigated in this study. Following metabolic labeling of R2D2...

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PMID: 8226951

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Defective galactofuranose addition in lipophosphoglycan biosynthesis in a mutant of Leishmania donovani.PMID 8226951Read ↗

Leishmania donovani lacking the Golgi GDP-Man transporter LPG2 exhibit attenuated virulence in mammalian hosts.Semantic proximity Read ↗

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Glycosylation defects and virulence phenotypes of Leishmania mexicana phosphomannomutase and dolicholphosphate-mannose synthase gene deletion mutants.Semantic proximity Read ↗

Isolation of virulence genes directing surface glycosyl-phosphatidylinositol synthesis by functional complementation of Leishmania.Semantic proximity Read ↗

Comparisons of mutants lacking the Golgi UDP-galactose or GDP-mannose transporters establish that phosphoglycans are important for promastigote but not amastigote virulence in Leishmania major.Semantic proximity Read ↗

Characterization of Leishmania donovani variant clones using anti-lipophosphoglycan monoclonal antibodies.Semantic proximity Read ↗

Lipophosphoglycan expression and virulence in ricin-resistant variants of Leishmania major.Semantic proximity Read ↗

Two Functionally Divergent UDP-Gal Nucleotide Sugar Transporters Participate in Phosphoglycan Synthesis in Leishmania majorSemantic proximity Read ↗

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