Article
Defective galactofuranose addition in lipophosphoglycan biosynthesis in a mutant of Leishmania donovani.
The Journal of biological chemistry - 15 Nov 1993
Huang C, Turco S J
Abstract excerpt
A mutant cell line of Leishmania donovani (R2D2), previously selected for resistance to the cytotoxic lectin ricin agglutinin, was found to be totally deficient in the synthesis and expression of lipophosphoglycan, a dominant surface virulence factor. The metabolic defect in R2D2 parasites respon...
Topics
- Animals
- Carbohydrate Sequence
- Cell-Free System
- Galactose
- Glycosphingolipids
- Leishmania donovani
- Mannose
- Molecular Sequence Data
- Mutation