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Article

The affected gene underlying the class K glycosylphosphatidylinositol (GPI) surface protein defect codes for the GPI transamidase.

Proceedings of the National Academy of Sciences of the United States of America - 11 Nov 1997

Yu J, Nagarajan S, Knez J J, Udenfriend S, Chen R, Medof M E

Abstract excerpt

The final step in glycosylphosphatidylinositol (GPI) anchoring of cell surface proteins consists of a transamidation reaction in which preassembled GPI donors are substituted for C-terminal signal sequences in nascent polypeptides. In previous studies we described a human K562 cell mutant, termed class K, that accumulates fully assembled GPI units but is unable to transfer them to N-terminally processed...

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Identifiers

PMID: 9356492
DOI: 10.1073/pnas.94.23.12580
PMCID: PMC25045

Genes

GPI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The affected gene underlying the class K glycosylphosphatidylinositol (GPI) surface protein defect codes for the GPI transamidase.PMID 9356492Read ↗

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