Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of a Leishmania mexicana mutant defective in synthesis of free and protein-linked GPI glycolipids.

Molecular and biochemical parasitology - 1 Jan 2000

Naderer Thomas, McConville Malcolm J

Abstract excerpt

The cell surface of the promastigote stage of the protozoan parasite, Leishmania mexicana is coated by a number of glycosylphosphatidylinositol (GPI)-anchored proteins, a GPI-anchored lipophosphoglycan (LPG) and an abundant class of free GPIs, termed glycoinositolphospholipids (GIPLs). We have de...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carbohydrate Sequence
Share to Concanavalin A
Share to Glycolipids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycosylphosphatidylinositols

Share to Life Cycle Stages

Share to Mannose

Share to Metalloendopeptidases

Share to Phospholipids

Source

Identifiers

PMID: 12467982
DOI: 10.1016/s0166-6851(02)00236-0

Genes

GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12467982-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of a Leishmania mexicana mutant defective in synthesis of free and protein-linked GPI glycolipids.PMID 12467982Read ↗

Evidence that free GPI glycolipids are essential for growth of Leishmania mexicana.Semantic proximity Read ↗

A glycosylphosphatidylinositol (GPI)-negative phenotype produced in Leishmania major by GPI phospholipase C from Trypanosoma brucei: topography of two GPI pathways.Semantic proximity Read ↗

Glycosylation defects and virulence phenotypes of Leishmania mexicana phosphomannomutase and dolicholphosphate-mannose synthase gene deletion mutants.Semantic proximity Read ↗

Genes for Glycosylphosphatidylinositol Toxin Biosynthesis inPlasmodium falciparumSemantic proximity Read ↗

The role of GlcNAc-PI-de-N-acetylase gene by gene knockout through homologous recombination and its consequences on survival, growth and infectivity of Leishmania major in in vitro and in vivo conditions.Semantic proximity Read ↗

Characterization of lipophosphoglycan from a ricin-resistant mutant of Leishmania major.Semantic proximity Read ↗

Defective galactofuranose addition in lipophosphoglycan biosynthesis in a mutant of Leishmania donovani.Semantic proximity Read ↗

Targeting the GPI biosynthetic pathwaySemantic proximity Read ↗

Elimination of GPI2 suppresses glycosylphosphatidylinositol GlcNAc transferase activity and alters GPI glycan modification in <i>Trypanosoma brucei</i>Semantic proximity Read ↗

Leishmania donovani lacking the Golgi GDP-Man transporter LPG2 exhibit attenuated virulence in mammalian hosts.Semantic proximity Read ↗

Disruption of mannose activation in Leishmania mexicana: GDP-mannose pyrophosphorylase is required for virulence, but not for viability.Semantic proximity Read ↗

Leishmania LPG3 encodes a GRP94 homolog required for phosphoglycan synthesis implicated in parasite virulence but not viability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.