Article
Altered insulin receptor messenger ribonucleic acid splicing in liver is associated with deterioration of glucose tolerance in the spontaneously obese and diabetic rhesus monkey: analysis of controversy between monkey and human studies.
The Journal of clinical endocrinology and metabolism - 1 Apr 1996
Huang Z, Bodkin N L, Ortmeyer H K, Zenilman M E, Webster N J, Hansen B C, Shuldiner A R
Abstract excerpt
There are two insulin receptor (IR) isoforms (designated type A and type B), derived from alternative splicing of exon 11 of the IR gene. Recently, we reported (Huang Z., Bodkin N.L., Ortmeyer H.K., Hansen B.C., Shuldiner A. R., 1994, J Clin Invest, 94:1289-1296) that an increase in the exon 11-...
Topics
- Alternative Splicing
- Animals
- Blood Glucose
- Diabetes Mellitus
- Diabetes Mellitus, Type 2
- Exons
- Genetic Variation
- Glucose Intolerance
- Humans
- Insulin Resistance
- Liver
- Macaca mulatta
- Obesity
- Prediabetic State