Article
Regulation of human insulin receptor RNA splicing in vivo.
Proceedings of the National Academy of Sciences of the United States of America - 15 Feb 1994
Norgren S, Zierath J, Wedell A, Wallberg-Henriksson H, Luthman H
Abstract excerpt
Alternative splicing involving the inclusion or exclusion of exon 11 in insulin receptor mRNA results in two isoforms of the alpha subunit. The two subunits display tissue-specific variation in relative abundance at both RNA and protein levels and discrete differences in biological properties. We...
Topics
- Alleles
- Alternative Splicing
- Base Sequence
- Biopsy
- DNA Primers
- Diabetes Mellitus, Type 2
- Exons
- Genome, Human
- Humans
- Insulin Resistance
- Male
- Middle Aged
- Molecular Sequence Data
- Muscles
- Polymerase Chain Reaction
- RNA, Messenger
- Receptor, Insulin
- Sequence Analysis, DNA