Article
Regulation of human insulin receptor RNA splicing in vivo.
Proceedings of the National Academy of Sciences of the United States of America - 15 Feb 1994
Norgren S, Zierath J, Wedell A, Wallberg-Henriksson H, Luthman H
Abstract excerpt
Alternative splicing involving the inclusion or exclusion of exon 11 in insulin receptor mRNA results in two isoforms of the alpha subunit. The two subunits display tissue-specific variation in relative abundance at both RNA and protein levels and discrete differences in biological properties. We have previously reported a small decrease in the relative level of RNA molecules lacking exon 11 (Ex 11-) in skeletal...
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