Article
Posttranscriptional mechanisms account for differences in steady state levels of insulin receptor messenger RNA in different cells.
Molecular endocrinology (Baltimore, Md.) - 1 May 1991
Tewari M, Tewari D S, Taub R
Abstract excerpt
Previous studies have indicated that, in general, the insulin receptor gene is expressed at a level in cells reflecting the level of insulin receptors on the cellular surface. For instance, insulin-responsive tissues, such as hepatocytes, express high levels of both insulin receptor protein and mRNA relative to less responsive cells, such as fibroblasts. Moreover, in the cells of a patient (Minn1) with severe...
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