Article
Insulinomas and expression of an insulin splice variant.
Lancet (London, England) - 31 Jan 2004
Minn Alexandra H, Kayton Mark, Lorang Dominique, Hoffmann Steven C, Harlan David M, Libutti Steven K, Shalev Anath
Abstract excerpt
BACKGROUND: Insulinomas are beta-cell tumours characterised by uncontrolled insulin secretion even in the presence of hypoglycaemia. However, the mechanisms allowing such excessive insulin secretion are not known. Insulin secretion can occur only when the beta-cell insulin stores have been replenished by insulin biosynthesis, which is mainly controlled by translation. Such specific translational regulation often...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.