Insulin receptor mRNA splicing and altered metabolic control in aged and mildly insulin-deficient rats.

doi:10.1152/ajpendo.1997.272.4.E607

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Article

Insulin receptor mRNA splicing and altered metabolic control in aged and mildly insulin-deficient rats.

The American journal of physiology - 1 Apr 1997

Wiersma M M, Auboeuf D, Nieuwenhuizen-Bakker I M, Radder J K, Riou J P, Vidal H

Abstract excerpt

Using reverse transcription-competitive polymerase chain reaction, we measured the abundance of the mRNAs encoding the two spliced isoforms of insulin receptor in aged and mildly insulin-deficient rats. Twelve-month-old rats were characterized by peripheral insulin resistance and decreased glucose tolerance. Mild insulin deficiency, obtained by neonatal streptozotocin treatment, was associated with glucose...

Topics

Aging
Alternative Splicing
Animals
Diabetes Mellitus, Experimental
Genetic Variation
Insulin
Insulin Resistance
Male
Polymerase Chain Reaction
RNA, Messenger
Rats
Rats, Wistar
Receptor, Insulin
Transcription, Genetic

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Identifiers

PMID: 9142881
DOI: 10.1152/ajpendo.1997.272.4.E607

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