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Article

Insulin receptor mRNA splicing and altered metabolic control in aged and mildly insulin-deficient rats.

The American journal of physiology - 1 Apr 1997

Wiersma M M, Auboeuf D, Nieuwenhuizen-Bakker I M, Radder J K, Riou J P, Vidal H

Abstract excerpt

Using reverse transcription-competitive polymerase chain reaction, we measured the abundance of the mRNAs encoding the two spliced isoforms of insulin receptor in aged and mildly insulin-deficient rats. Twelve-month-old rats were characterized by peripheral insulin resistance and decreased glucose tolerance. Mild insulin deficiency, obtained by neonatal streptozotocin treatment, was associated with glucose...

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Identifiers

PMID: 9142881
DOI: 10.1152/ajpendo.1997.272.4.E607

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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