Article
In vitro competitive inhibition of plasma cholinesterase by cocaine: normal and variant genotypes.
Journal of toxicology. Clinical toxicology - 1 Jan 1996
Schwartz H J, Johnson D
Abstract excerpt
OBJECTIVE: To determine the inhibitory constant, Ki, of cocaine for a number of the different genetic variants of human plasma cholinesterase. DESIGN: In vitro analysis of plasma cholinesterase activity in the presence of cocaine as a competitive inhibitor. METHODS: Six normal (UU) control sera and seven sera with the following plasma cholinesterase genotypes were assayed: AA, UA, AS, UF, US, AF and SS. Plasma...
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