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Article

Substrate selectivity of high-activity mutants of human butyrylcholinesterase.

Organic & biomolecular chemistry - 21 Nov 2013

Hou Shurong, Xue Liu, Yang Wenchao, Fang Lei, Zheng Fang, Zhan Chang-Guo

Abstract excerpt

Cocaine is one of the most addictive drugs, and there is still no FDA (Food and Drug Administration)-approved medication specific for cocaine abuse. A promising therapeutic strategy is to accelerate cocaine metabolism, producing biologically inactive metabolites via a route similar to the primary cocaine-metabolizing pathway, i.e. cocaine hydrolysis catalyzed by butyrylcholinesterase (BChE) in plasma. However,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24077614
DOI: 10.1039/c3ob41713a
PMCID: PMC3836059

Genes

BTC

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