Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Amelioration of the cardiovascular effects of cocaine in rhesus monkeys by a long-acting mutant form of cocaine esterase.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Apr 2011

Collins Gregory T, Carey Kathy A, Narasimhan Diwahar, Nichols Joseph, Berlin Aaron A, Lukacs Nicholas W, Sunahara Roger K, Woods James H, Ko Mei-Chuan

Abstract excerpt

A long-acting mutant form of a naturally occurring bacterial cocaine esterase (T172R/G173Q CocE; double mutant CocE (DM CocE)) has previously been shown to antagonize the reinforcing, convulsant, and lethal effects of cocaine in rodents. However, the effectiveness and therapeutic characteristics of DM CocE in nonhuman primates, in a more clinically relevant context, are unknown. The current studies were aimed at...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Temperature
Share to Carboxylic Ester Hydrolases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cardiovascular System

Share to Cocaine

Share to Dopamine Uptake Inhibitors

Share to Heart Rate

Share to Injections, Intravenous

Share to Macaca mulatta

Source

Open in PubMed Open full text

Identifiers

PMID: 21289605
DOI: 10.1038/npp.2010.242
PMCID: PMC3076304

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Amelioration of the cardiovascular effects of cocaine in rhesus monkeys by a long-acting mutant form of cocaine esterase.PMID 21289605Read ↗

Evaluation of the hydrolytic activity of a long-acting mutant bacterial cocaine in the presence of commonly co-administered drugs.Semantic proximity Read ↗

Structural analysis of thermostabilizing mutations of cocaine esteraseSemantic proximity Read ↗

Accelerating cocaine metabolism as an approach to the treatment of cocaine abuse and toxicity.Semantic proximity Read ↗

Amino-acid mutations to extend the biological half-life of a therapeutically valuable mutant of human butyrylcholinesterase.Semantic proximity Read ↗

Prolonged toxic effects after cocaine challenge in butyrylcholinesterase/plasma carboxylesterase double knockout mice: a model for butyrylcholinesterase-deficient humans.Semantic proximity Read ↗

Rational design, preparation, and characterization of a therapeutic enzyme mutant with improved stability and function for cocaine detoxification.Semantic proximity Read ↗

Catalytic activities of cocaine hydrolases against the most toxic cocaine metabolite norcocaethylene.Semantic proximity Read ↗

β-Blockers for ED Presentations with Recent Cocaine Use: A Systematic ReviewSemantic proximity Read ↗

Review of human butyrylcholinesterase structure, function, genetic variants, history of use in the clinic, and potential therapeutic uses.Semantic proximity Read ↗

An improved cocaine hydrolase: the A328Y mutant of human butyrylcholinesterase is 4-fold more efficient.Semantic proximity Read ↗

Gene transfer of mutant mouse cholinesterase provides high lifetime expression and reduced cocaine responses with no evident toxicity.Semantic proximity Read ↗

Plant-expressed cocaine hydrolase variants of butyrylcholinesterase exhibit altered allosteric effects of cholinesterase activity and increased inhibitor sensitivity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.