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Article

Evaluation of the hydrolytic activity of a long-acting mutant bacterial cocaine in the presence of commonly co-administered drugs.

Drug and alcohol dependence - 15 Dec 2011

Brim Remy L, Noon Kathleen R, Nichols Joseph, Narasimhan Diwahar, Woods James H, Sunahara Roger K

Abstract excerpt

BACKGROUND: Cocaine toxicity is a prevalent problem in the Unites States for which there is currently no FDA-approved pharmacotherapy. We have developed a bacterial cocaine esterase (CocE) towards this indication. A thermostabilized mutant of CocE (DM-CocE) retains the hydrolytic activity of the wild-type esterase, rapidly hydrolyzing cocaine into the inactive metabolites ecgonine methyl ester and benzoic acid,...

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Source

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Identifiers

PMID: 21775073
DOI: 10.1016/j.drugalcdep.2011.06.018
PMCID: PMC3217061

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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