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Article

Accelerating cocaine metabolism as an approach to the treatment of cocaine abuse and toxicity.

Future medicinal chemistry - 1 Feb 2012

Schindler Charles W, Goldberg Steven R

Abstract excerpt

One pharmacokinetic approach to the treatment of cocaine abuse and toxicity involves the development of compounds that can be safely administered to humans and that accelerate the metabolism of cocaine to inactive components. Catalytic antibodies have been developed and shown to accelerate cocaine metabolism, but their catalytic efficiency for cocaine is relatively low. Mutations of human butyrylcholinesterase...

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Identifiers

PMID: 22300096
DOI: 10.4155/fmc.11.181
PMCID: PMC3293209

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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