Article
Prolonged toxic effects after cocaine challenge in butyrylcholinesterase/plasma carboxylesterase double knockout mice: a model for butyrylcholinesterase-deficient humans.
Drug metabolism and disposition: the biological fate of chemicals - 1 Aug 2011
Duysen Ellen G, Lockridge Oksana
Abstract excerpt
Death and toxicity after cocaine use do not correlate with cocaine blood levels. One explanation for this observation is that cocaine abusers may posses one or more of the 58 possible known mutations in the butyrylcholinesterase gene (BCHE). Butyrylcholinesterase (BChE) serves as the primary cocaine hydrolase producing a nontoxic product ecgonine methyl ester. A reduction in endogenous levels of BChE may result...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.