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Article

Suppression of amber nonsense mutations of herpes simplex virus type 1 in a tissue culture system.

The Journal of general virology - 1 Feb 1996

Patel A H, Subak-Sharpe J H, Stow N D, Marsden H S, Maclean J B, Dargan D J

Abstract excerpt

We have investigated the ability of monkey kidney cell lines (SupD3 and SupD12) inducibly expressing an amber suppressor tRNA(ser) to suppress amber nonsense mutations in three genes of herpes simplex virus type 1 (HSV-1). HSV-1 mutant TK4, which contains a nonsense mutation in the non-essential viral thymidine kinase (TK) gene, synthesized a full-length TK polypeptide at about 30% of the wild-type (wt) level in...

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PMID: 8627223
DOI: 10.1099/0022-1317-77-2-199

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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