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Article

Conserved aspartic acid 233 and alanine 231 are not required for poliovirus polymerase function in replicons.

Virology journal - 12 Mar 2007

Freistadt Marion S, Eberle Karen E

Abstract excerpt

Nucleic acid polymerases have similar structures and motifs. The function of an aspartic acid (conserved in all classes of nucleic acid polymerases) in motif A remains poorly understood in RNA-dependent RNA polymerases. We mutated this residue to alanine in a poliovirus replicon. The resulting mutant could still replicate, although at a reduced level. In addition, mutation A231C (also in motif A) yielded high...

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Identifiers

PMID: 17352827
DOI: 10.1186/1743-422X-4-28
PMCID: PMC1839082

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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