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Article

Germinal center founder cells display propensity for apoptosis before onset of somatic mutation.

The Journal of experimental medicine - 3 Feb 1997

Lebecque S, de Bouteiller O, Arpin C, Banchereau J, Liu Y J

Abstract excerpt

B lymphocytes undergo affinity maturation of their antigen receptors within germinal centers. These anatomical structures develop in secondary lymphoid organs from the clonal expansion of a few antigen-specific founder B cells, whose isolation and characterization are reported here. Human germinal center founder cells express the naive B cell markers surface IgM and IgD as well as the germinal center B cell...

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Identifiers

PMID: 9053456
DOI: 10.1084/jem.185.3.563
PMCID: PMC2196025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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