Article
Germinal center founder cells display propensity for apoptosis before onset of somatic mutation.
The Journal of experimental medicine - 3 Feb 1997
Lebecque S, de Bouteiller O, Arpin C, Banchereau J, Liu Y J
Abstract excerpt
B lymphocytes undergo affinity maturation of their antigen receptors within germinal centers. These anatomical structures develop in secondary lymphoid organs from the clonal expansion of a few antigen-specific founder B cells, whose isolation and characterization are reported here. Human germina...
Topics
- ADP-ribosyl Cyclase
- ADP-ribosyl Cyclase 1
- Animals
- Antigens, CD
- Antigens, Differentiation
- Apoptosis
- B-Lymphocytes
- Flow Cytometry
- Germinal Center
- Humans
- Immunoglobulin D
- Immunoglobulin M
- Membrane Glycoproteins
- Mice
- Mice, Inbred BALB C
- Mutation
- N-Glycosyl Hydrolases