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Article

A novel human B cell subpopulation representing the initial germinal center population to express AID.

Blood - 15 Mar 2007

Kolar Grant R, Mehta Darshna, Pelayo Rosana, Capra J Donald

Abstract excerpt

We have identified a novel mature human B-cell subpopulation in the human tonsil that has characteristics of both naive B cells and germinal center B cells including the expression of activation-induced cytidine deaminase (AID), which is essential for the process of immunoglobulin somatic hypermutation and class-switch recombination. These cells are clearly somatically hypermutated, albeit modestly. Their...

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Identifiers

PMID: 17132718
DOI: 10.1182/blood-2006-07-037150
PMCID: PMC1852199

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Source receipt: pubmed, retrieved 7 Sept 2026.

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