Article
Rate of thymidine analogue resistance mutation accumulation with zidovudine- or stavudine-based regimens.
Journal of acquired immune deficiency syndromes (1999) - 1 May 2004
Kuritzkes Daniel R, Bassett Roland L, Hazelwood J Darren, Barrett Heidi, Rhodes Ruth A, Young Russell K, Johnson Victoria A
Abstract excerpt
Zidovudine (ZDV) and stavudine (d4T) select for the same set of thymidine analogue resistance mutations (TAMs). To compare the rate at which TAMs emerge, genotypic analysis of HIV-1 was performed on serial plasma samples from treatment-naive subjects randomly assigned to receive ZDV or d4T in com...
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