Genotypic evolution of HIV-1 isolates from patients after a switch of therapy from zidovudine to didanosine.

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Article

Genotypic evolution of HIV-1 isolates from patients after a switch of therapy from zidovudine to didanosine.

Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association - 1 Apr 1995

Masquelier B, Pellegrin I, Ruffault A, Ragnaud J M, Morlat P, Michelet C, Doignon F, Biteau N, Fleury H J

Abstract excerpt

The existence of zidovudine (ZDV)-resistant and didanosine (ddI)-resistant human immunodeficiency-1 (HIV-1) variants mutated in the reverse transcriptase (RT) gene has been previously demonstrated. In this study, we tried to follow up the genotypic changes in the RT after the switch of therapy from ZDV to ddI. We studied HIV-1 isolates from 11 patients undergoing ddI therapy. Genotypic data were obtained with...

Topics

Base Sequence
Biological Evolution
DNA Primers
DNA, Viral
Didanosine
Drug Resistance, Microbial
Genotype
HIV Infections
HIV Reverse Transcriptase
HIV-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Leukocytes, Mononuclear

Molecular Sequence Data

Mutation

Phenotype

Polymerase Chain Reaction

RNA-Directed DNA Polymerase

Zidovudine

Source

Open in PubMed

Identifiers

PMID: 7533640

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7533640-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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