Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hepatoma-derived integrated HBV DNA causes multi-stage transformation in vitro.

Oncogene - 18 Apr 1996

Luber B, Arnold N, Stürzl M, Höhne M, Schirmacher P, Lauer U, Wienberg J, Hofschneider P H, Kekulé A S

Abstract excerpt

The hepatoma-derived hepatitis B virus (HBV) DNA insert HU-a has recently been shown to contain two viral transactivator genes, X and preS2 /S. We report here that HU-a induces malignant transformation after stable transfection of the fetal mouse hepatocyte line FMH202, as indicated by soft agar growth and nude mouse tumorigenicity. Transfections with HU-a subclones, containing the X gene of the preS2 /S gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Transformation, Neoplastic
Share to Chromosome Aberrations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Transposable Elements

Share to DNA, Viral

Share to Liver Neoplasms

Share to Mice, Inbred BALB C

Share to Phenotype

Source

Identifiers

PMID: 8622879

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hepatoma-derived integrated HBV DNA causes multi-stage transformation in vitro.PMID 8622879Read ↗

Hepatitis B virus-induced oncogenesis.Semantic proximity Read ↗

The preS2/S region of integrated hepatitis B virus DNA encodes a transcriptional transactivator.Semantic proximity Read ↗

Modeling Hepatitis B Virus X–Induced Hepatocellular Carcinoma in Mice With the Sleeping Beauty Transposon System ΔSemantic proximity Read ↗

Synergistic function of Kras mutation and HBx in initiation and progression of hepatocellular carcinoma in mice.Semantic proximity Read ↗

Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis.Semantic proximity Read ↗

Hepatitis B virus transcriptional activators: mechanisms and possible role in oncogenesisSemantic proximity Read ↗

Hepatitis B virus X mutants derived from human hepatocellular carcinoma retain the ability to abrogate p53-induced apoptosis.Semantic proximity Read ↗

Latent hepatitis B virus (HBV) infection and HBV DNA integration is associated with further transformation of hepatoma cells in vitro.Semantic proximity Read ↗

ras transformation of simian virus 40-immortalized rat hepatocytes: an in vitro model of hepatocarcinogenesis.Semantic proximity Read ↗

Initial sites of hepadnavirus integration into host genome in human hepatocytes and in the woodchuck model of hepatitis B-associated hepatocellular carcinomaSemantic proximity Read ↗

Selective accumulation of the X transcript of hepatitis B virus in patients negative for hepatitis B surface antigen with hepatocellular carcinomaSemantic proximity Read ↗

Integration of hepatitis B virus DNA and its implications for hepatocarcinogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.