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Article

p21 is a critical CDK2 regulator essential for proliferation control in Rb-deficient cells.

The Journal of cell biology - 20 Apr 1998

Brugarolas J, Bronson R T, Jacks T

Abstract excerpt

Proliferation in mammalian cells is controlled primarily in the G1-phase of the cell cycle through the action of the G1 cyclin-dependent kinases, CDK4 and CDK2. To explore the mechanism of cellular response to extrinsic factors, specific loss of function mutations were generated in two negative regulators of G1 progression, p21 and pRB. Individually, these mutations were shown to have significant effects in G1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 9548727
DOI: 10.1083/jcb.141.2.503
PMCID: PMC2148461

Genes

CDK2
CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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p21 is a critical CDK2 regulator essential for proliferation control in Rb-deficient cells.PMID 9548727Read ↗

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