Article
Ahr locus phenotype in congenic mice influences hepatic and pulmonary DNA adduct levels of 2-amino-3-methylimidazo[4,5-f]quinoline in the absence of cytochrome P450 induction.
Molecular pharmacology - 1 May 1996
Nerurkar P V, Schut H A, Anderson L M, Riggs C W, Fornwald L W, Davis C D, Snyderwine E G, Thorgeirsson S S, Weber W W, Rice J M, Levy G N
Abstract excerpt
The potent food mutagen/carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) undergoes metabolic N-hydroxylation by cytochromes P450, including cytochrome P450 1A2, followed by generation of an unstable ester catalyzed by acetyltransferases; promutagenic DNA adducts result. Genetic polymorphisms in these enzymes have been implicated in human cancer risk related to arylamine exposure. We investigated the...
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