Article
2-Aminofluorene-DNA adducts in mouse urinary bladder: effect of age, sex and acetylator phenotype.
Carcinogenesis - 1 Feb 1992
Levy G N, Weber W W
Abstract excerpt
Formation of urinary bladder DNA-2-aminofluorene adducts in inbred and acetylator congenic mice was measured 3 h after a 60 mg/kg dose of the arylamine carcinogen. The sensitivity of 32P-postlabeling with HPLC analysis permitted quantitation of adducts in individual mouse bladders. Acetylator phenotype was a significant determinant of DNA damage in female mice as slow acetylators had higher levels of bladder DNA...
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