2-Aminofluorene-DNA adducts in mouse urinary bladder: effect of age, sex and acetylator phenotype.

doi:10.1093/carcin/13.2.159

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Article

2-Aminofluorene-DNA adducts in mouse urinary bladder: effect of age, sex and acetylator phenotype.

Carcinogenesis - 1 Feb 1992

Levy G N, Weber W W

Abstract excerpt

Formation of urinary bladder DNA-2-aminofluorene adducts in inbred and acetylator congenic mice was measured 3 h after a 60 mg/kg dose of the arylamine carcinogen. The sensitivity of 32P-postlabeling with HPLC analysis permitted quantitation of adducts in individual mouse bladders. Acetylator phenotype was a significant determinant of DNA damage in female mice as slow acetylators had higher levels of bladder DNA...

Topics

Acetylation
Age Factors
Animals
Carcinogens
Chromatography, High Pressure Liquid
DNA
DNA Adducts
DNA Damage
Female
Fluorenes
Injections, Intraperitoneal
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred A

Mice, Inbred C57BL

Phenotype

Sex Factors

Urinary Bladder

Source

Open in PubMed

Identifiers

PMID: 1740004
DOI: 10.1093/carcin/13.2.159

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1740004-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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