Article
Differential effects of the swedish mutant amyloid precursor protein on beta-amyloid accumulation and secretion in neurons and nonneuronal cells.
The Journal of biological chemistry - 19 Dec 1997
Forman M S, Cook D G, Leight S, Doms R W, Lee V M
Abstract excerpt
Expression of the Swedish DeltaNL mutation in the beta-amyloid precursor protein (APPDeltaNL) dramatically increases Abeta generation in nonneuronal cell lines, although it is unclear whether intracellular levels of beta-amyloid (Abeta) are also elevated after APPDeltaNL expression. Furthermore,...
Topics
- Amino Acid Sequence
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Animals
- CHO Cells
- Cricetinae
- Humans
- Molecular Sequence Data
- Mutation
- Neurons
- Rats