Proportion of DNA gyrase mutants among quinolone-resistant strains of Pseudomonas aeruginosa.

doi:10.1128/AAC.34.6.1273

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Article

Proportion of DNA gyrase mutants among quinolone-resistant strains of Pseudomonas aeruginosa.

Antimicrobial agents and chemotherapy - 1 Jun 1990

Yoshida H, Nakamura M, Bogaki M, Nakamura S

Abstract excerpt

The proportion of DNA gyrase mutants among quinolone-resistant strains of Pseudomonas aeruginosa was examined by introducing the cloned wild-type Escherichia coli gyrA and gyrB genes. Of 101 spontaneous mutants of P. aeruginosa PAO505, 33 (33%) were found to have gyrA mutations. Among 17 clinical...

Topics

4-Quinolones
Anti-Infective Agents
DNA Topoisomerases, Type II
Drug Resistance, Microbial
Mutation
Pseudomonas aeruginosa
Transformation, Genetic

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